Abstract Title
Lactobacillus rhamnosus Binds with GII.4 Human Noroviruses and Inhibits the Viral Replication in Zebrafish Larvae
Presenter
Dapeng Wang, SJTU
Co-Author(s)
Yaqi Yang, Dapeng Wang
Abstract Category
Interaction between Calicivirus and host microbiota
Abstract
Human noroviruses (HuNoVs) are the primary cause of viral gastroenteritis globally. Nevertheless, available anti-HuNoVs approaches remains limited. Current study revealed that a Lactobacillus rhamnosus strain, i.e., Lactobacillus rhamnosus YQ001, originated MRS based fermentation broth (FB) and cell free supernatant (CFS) could significantly inhibit the replication of HuNoVs in zebrafish larvae (Danio rerio), reducing viral RNA titers up to 2 log10 and 1 log10 copies, respectively. In addition, the inhibition effect of FB was significantly stronger than that of CFS (p