Metagenomic Analysis of Enteropathogenic Diversity Using Next-Generation Sequencing in Norovirus-Positive Stool Samples from Children Under 3 Years of Age Hospitalized With Acute Gastroenteritis at Dr. Luis Calvo Mackenna Hospital, Santiago, Chile

Carlos Garrido, University of Antofagasta

Carlos Garrido-Soto ¹ ³; Richard A. Olivares¹ ² ³; Mariella Rivas¹ ³; Mauricio J. Farfán⁴; Jan Vinje⁵; Margarita K. Lay¹ ² ³ ¹ Department of Biotechnology, University of Antofagasta, Antofagasta, Chile ² Millennium Institute on Immunology and Immunotherapy, University of Antofagasta, Chile ³ Research Center for Immunology and Biomedical Biotechnology of Antofagasta (CIIBBA), University of Antofagasta, Antofagasta, Chile ⁴ Molecular Biology Laboratory, Hospital Dr. Luis Calvo Mackenna, Santiago, Chile ⁵ National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia

Molecular Epidemiology & Evolution

Human noroviruses (HuNoV) are the leading cause of acute gastroenteritis (AGE), with high morbidity worldwide, especially in children under 5 years, immunocompromised individuals and the elderly. Often, AGE cases involve co-infection by multiple enteric pathogens. In this study, 11 norovirus-positive stool samples from pediatric patients (