Abstract Title
Perceived Health Status among Patients with Norovirus and Acute Gastroenteritis
Presenter
Holly Groom, Kaiser Permanente Center for Health Research
Co-Author(s)
Holly C. Groom MPH1, Matthew T. Slaughter MS1, Emma Viscidi PhD2, John Dickerson, PhD1, Maureen O’Keeffe-Rosetti MS1, Judy Donald1, Carly A. Crocker BS2, Wen-Hsing Wu MS2, Michelle Blake, PhD2, Philip O. Buck, PhD2, Katherine B. Carlson, PhD2, Mark Schmidt, PhD1,3
1Kaiser Permanente Center for Health Research, Portland, OR, USA
2Moderna, Inc. Cambridge, MA USA
3Kaiser Permanente Bernard J Tyson School of Medicine, Pasadena, CA USA
Abstract Category
Epidemology
Abstract
Objective: To assess the impact of norovirus (NoV) on health-related quality of life (HRQoL) among individuals with medically-attended acute gastroenteritis (MAAGE) aged 5 years and older.
Methods: Study of Acute Gastroenteritis (SAGE) was a prospective study conducted from November 2023-September 2024 at an integrated healthcare system in Oregon and Washington, US. Participants presenting with MAAGE completed an enrollment survey and provided a stool specimen for NoV testing. The survey included the EuroQoL (EQ-5D-5L), a validated HRQoL instrument, to assess participant-perceived health status, including a visual analog scale (VAS) to rate health from 0 (worst health) to 100 (best health). Participants completed the EQ-5D twice, reporting how they felt before, then on their worst day of AGE illness. Decrements in VAS were compared between timepoints by norovirus positivity and age group, using Wilcoxon rank-sum tests.
Results: Our analysis included 772 adults; 119 (15%) NoV-positive and 653 NoV-negative, and 34 children aged 5-17 years, 15 (44%) NoV-positive and 19 NoV-negative. Caregivers of NoV-positive children reported a median VAS decrement of 70, compared to 44 among NoV-negative children (p
Methods: Study of Acute Gastroenteritis (SAGE) was a prospective study conducted from November 2023-September 2024 at an integrated healthcare system in Oregon and Washington, US. Participants presenting with MAAGE completed an enrollment survey and provided a stool specimen for NoV testing. The survey included the EuroQoL (EQ-5D-5L), a validated HRQoL instrument, to assess participant-perceived health status, including a visual analog scale (VAS) to rate health from 0 (worst health) to 100 (best health). Participants completed the EQ-5D twice, reporting how they felt before, then on their worst day of AGE illness. Decrements in VAS were compared between timepoints by norovirus positivity and age group, using Wilcoxon rank-sum tests.
Results: Our analysis included 772 adults; 119 (15%) NoV-positive and 653 NoV-negative, and 34 children aged 5-17 years, 15 (44%) NoV-positive and 19 NoV-negative. Caregivers of NoV-positive children reported a median VAS decrement of 70, compared to 44 among NoV-negative children (p