Session Title: Essential cellular factor(s) for human sapovirus propagation

Oral Abstracts: 

• Development of an ex vivo model to study the zoonotic transmission of noroviruses
  • Nele Villabruna, University of Veterinary Medicine Hanover
• Dysregulated innate epithelial response to norovirus infection in intestinal organoids from patients with common variable immunodeficiency
  • Magdalena Neijd, Linköping University, Sweden
• Human Norovirus Replicates in Hepatocytes and Other Liver Cells in Zebrafish Larvae    
  • Lorane Molineaux, KU Leuven

Oral Abstracts: 

• Intercellular calcium waves are a conserved feature of enteric virus infection and drive Tulane virus spread
  • Joseph Hyser, Baylor College of Medicine
• Norovirus alters host metabolism for efficient virus replication
  • Adam Hafner, University of Michigan
• Overcoming host restriction to enable continuous passaging of human noroviruses in human intestinal enteroids
  • Gurpreet Kaur, Baylor College of Medicine
• Single-cell transcriptomic analysis of duodenal biopsies and enteroids from immunocompromised patients with chronic norovirus infection
  • Yuki Matsushima, Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health

Session Title: Norovirus pathogenesis: from cell death to transmission

Oral Abstracts:

• Mutational Analysis of Human Norovirus VP2 Elucidates Critical Molecular Interactions for Virus Assembly
  • Sue Crawford, Baylor College of Medicine
• Structural studies of the calcivirus entry pathway – conformational flexibility as a marker of virulence?
  • David Bhella, MRC - University of Glasgow Centre for Virus Research
• Structure of the Norovirus NTPase
  • Daniel Hurdiss, Utrecht University

Oral Abstracts: 

• CRISPR-Cas13a Coupled with a Capsid Integrity Assay for Detecting Norovirus in Food
  • Axel Ossio, Universidad Autonoma de Nuevo Leon
• Evaluation of sensitivity and specificity of New Immunochromatograpghy (IC) kit for the rapid detection of norovirus associated acute gastroenteritis in Dhaka, Bangladesh
  • Shuvra Kanti Dey, Jahangirnagar University

Session Title: Proteomics as a complementary approach to measure norovirus infection in clinical samples

Oral Abstracts: 

• Burden of viral pathogens causing acute gastroenteritis in children less than 2 years of age in a U.S. birth cohort
  • Jennifer Cannon, CDC Foundation
• Comparing Norovirus Gastroenteritis in Medically-Attended Patients and Community-Cohort in Central Wisconsin, United States
  • Joshua Petrie, Marshfield Clinic Research Institute
• Gastrointestinal viral Infection in Adult and Pediatric Solid Organ Transplant Recipient: A Retrospective, Single-center Study from 2015 to 2022
  • Varalika Tyagi, University of Alberta
• Human milk oligosaccharides and norovirus GII gastroenteritis in a Nicaraguan birth cohort
  • Rebecca Rubinstein, University of North Carolina at Chapel Hilll

Oral Abstracts: 

• Molecular Characterization of Human Noroviruses among Children with Acute Gastroenteritis in Ebonyi State, Nigeria
  • Olumuyiwa Babalola Salu, College of Medicine, University of Lagos
• Norovirus and Sapovirus Associated Chronic Diarrhea in SOT: Does Viral Load Correlate with Severity of Symptoms?
  • Varalika Tyagi, University of Alberta
• Norovirus Shedding in Symptomatic and Asymptomatic Patients: Insights from a Tertiary Care Hospital-Based Study in Bangladesh
  • Syed Moinuddin Satter, icddr,b
• Sporadic, Medically Attended Norovirus Infection in the United States, 2023-2024
  • Mark Schmidt, Kaiser Permanente Center for Health Research

Session Title: Using murine norovirus to decipher mechanisms of adaptive immune control

Session Title: The saga to monitor and control norovirus: the rise and fall of variants

Oral Abstracts: 

• Characterization of Binding and Antigenic Properties in Emerging GII.17 Norovirus Variants
  • Francisco Morais Esteves, Erasmus MC
• Characterization of human norovirus and host genetic susceptibility profiling in South African children with gastroenteritis
  • Ronewa Khumela, University of Pretoria
• Dynamics of asymptomatic Norovirus infections in a three-year cohort of children from rural communities in Ecuador
  • Rommel Guevara, Universidad San Francisco de Quito
• Emergence of GII.3 as most prevalent norovirus strain among infants and children with acute gastroenteritis in Bangladesh
  • Shuvra Kanti Dey, Jahangirnagar University

Oral Abstracts: 

• Genotypic distribution and molecular epidemiology of norovirus among under-five children hospitalized with acute gastroenteritis in South India, 2005-2020
  • Tintu Varghese, Christian Medical College Vellore
• Global trends in norovirus genotype distribution among children with acute gastroenteritis captured by NoroSurv, 2020-2025
  • Jennifer Cannon, CDC Foundation
• Increased norovirus activity associated with the emergence of GII.17[P17] in season 2023/24 in Germany
  • Sandra Niendorf, Robert Koch Institute
• Molecular Characterization and Isolation of Contemporary Porcine Sapoviruses from Swine Farms in the United States
  • Qiuhong Wang, The Ohio State University
• Screening Norovirus Genetic Diversity in Public Datasets using Aitne, a Novel Open Source Genotyper
  • Dennis Schmitz, Erasmus Medical Center / Netherlands Institute of Public Health and the Environment (RIVM)

Oral Abstracts: 

• Antigenic characterization of human noroviruses reveals limited cross-blocking between genotypes
  • Lauren Ford-Siltz, Food and Drug Administration
• Efficacy, safety, immunogenicity, and cross-reactivity of intramuscular HIL-214 norovirus vaccine in healthy children 5 Months of age at initial vaccination
  • Michael Abram, Robert Hershberg, HilleVax
• Milk IgAs of early life origin B cells have cross-neutralizing antiviral properties
  • Hannah Karen Labayo, NIH-NHLBI
• Next Generation Oral Norovirus Vaccine Candidate Generates Improved Immune Responses to GI.I and GII.4 strains in Humans
  • Sean N. Tucker, Vaxart, Inc.

Oral Abstracts: 

• Neutralizing antibody responses to GII.4 vaccination from early childhood through old age: harnessing the power of immune imprinting to drive breadth
  • Lisa Lindesmith, University of North Carolina-Chapel Hill
• Safety and Immunogenicity of mRNA-1403, a Multivalent Norovirus mRNA Vaccine, in Healthy Adults: Interim Results of a Phase 1/2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Trial
  • Meklit Workneh, Moderna
• Targeting the Gut: Oral Norovirus Vaccine Generates Protective Mucosal Immunity and Reduces Viral Shedding Following GI.1 Challenge
  • Becca Flitter, Vaxart
• Repertoire of naturally acquired norovirus maternal antibodies in newborns
  • Verónica Costantini, Centers for Disease Control and Prevention

Session Title: Enteric Viruses in Food Systems: From Occurrence to Control 

Oral Abstracts: 

• Direct comparison of the persistence of infectious human norovirus and its cultivable surrogate, hepatitis A virus, on frozen raspberries
  • Émilie Larocque, Canadian Food Inspection Agency
• The final straw: berries and viruses
  • Malak Esseili, University of Georgia
• Challenges in the culture of norovirus isolated from oyster tissues
  • Marion Desdouits, Ifremer

Session Title: Capture-based metaviromics to describe caliviridae diversity in contaminated shellfish

Oral Abstracts: 

• Wastewater-based epidemiology at a global scale for norovirus surveillance: From metagenomics to phenotypical characterization
  • Ray William Izquierdo Lara, Erasmus MC
• Wastewater-based Surveillance of Norovirus and Sapovirus from 2020 - 2024 in Alberta, Canada
  • Judy Qiu, Alberta Public Health Laboratory/University of Alberta

Shuttles depart the Banff Centre at 5:45pm.

Oral Abstracts:

• VIRTUAL PRESENTATION: Development of Reporter Replicon Systems for Genogroup II Human Noroviruses: Tools for Antiviral Screening and Mechanistic Insight & Evaluation of MMV Pandemic Response Box compounds identifies MMP-inhibitor against HuNoV replication
  • ​​​​​​​Myra Hosmillo, University of Cambridge
• Oral Direct-Acting Antiviral CDI-988 for norovirus infection prevention and treatment: Mechanism of Action and Phase 1 Study Results
  • Sam Lee, Cocrystal Pharma Inc.
• Polyamine depletion inhibits norovirus infection and blocks virus-induced apoptosis
  • Stefan Taube, University of Lübeck
• Targeting calicivirus entry – a VP2 peptide inhibitor of Feline Calicivirus
  • Charlotte Lewis, University of Glasgow Centre for Virus Research